NCT02361398已完成不适用
Individualized Positive End Expiratory Pressure(PEEP) Setting by EIT in Patients With Acute Respiratory Distress Syndrome(ARDS)
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- survival
研究概览
简要总结
The investigators conducted a pilot study to compare the effect of Positive End Expiratory Pressure(PEEP) setting guide by lung electrical impedance tomography(EIT) and ARDS-net PEEP-FiO2 table on survival in subjects with mild/severe Acute Respiratory Distress Syndrome(ARDS).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)<300 and PEEP >5cmH2O
- •Body mass index < =40
- •Written inform consent
排除标准
- •pregnant，intracranial hypertension
- •left ventricular dysfunction (EF<25% )
- •Patients with end-stage conditions(death expected within 90 days)
研究组 & 干预措施
control group
No Intervention
If patients are assigned to the control group, the Individualized PEEP Setting was by PEEP-FiO2 table based on ARDS-net protocol.
EIT group
Experimental
the Individualized PEEP titration by EIT was administered to the patients in the EIT group.
干预措施: the EIT guide the individualized PEEP Setting (Other)
结局指标
主要结局
survival
时间窗: 28-day
Non-survive and survive
Arterial oxygenation
时间窗: 72h
PaO2(mmHg) measured by blood gas analysis
次要结局
- length of ICU stay and mechanical ventilated day(28days)
- pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days;(7days)
研究者
研究点 (1)
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