Effect of cooling in aerobic exercise on fatigue and physical performance for people with Multiple Sclerosis: A preliminary crossover trial

Chris Barr0 个研究点目标入组 60 人开始时间: 2012年8月15日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•MS Subjects fulfilling the following criteria will be eligible to participate in this study:
•Definite diagnosis of MS;
•Mild to moderate difficulty in ambulation with Expanded Disability Status Scale (EDSS) 2.0 – 5.0;
•Able and agree to engage in maximal exercise test with minimal work load above 30 watts, which is the starting workload of graded incremental cycling test;
•Able to walk independently;
•Self-report in problem with fatigue;
•Able to understand instructions and give informed consent
•Inclusion criteria for healthy participants:
•Healthy male or female
•Over 18 years of age

•The exclusion criteria include:
•Use of medication prescribed for fatigue management (e.g Amantadine, Modafinil);
•Currently participates in other clinical trials or exercise program;
•Suffering from an exacerbation or relapse of MS within the past 3 months;
•Severe depression;
•Suffering form other neural, cardiovascular, orthopaedic or muscular disease besides MS;
•Gastroesophageal disease or dysphagia which has difficulty in swallowing the disposable silicon-coated pill to measure core temperature;
•Diverticulitis, which is a digestive disease could affect bowel and become contraindication to pill ingestion;
•Subject who is known to be pregnant;
•Subject with blood clotting problem prone to bleeding complications in blood lactate testing;
•Known illness or infection

发起方

Chris Barr