Effect of cooling in aerobic exercise on fatigue and physical performance for people with Multiple Sclerosis: A preliminary crossover trial
- Conditions
- Fatigue in people with multiple sclerosisNeurological - Multiple sclerosis
- Registration Number
- ACTRN12612000862842
- Lead Sponsor
- Chris Barr
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
MS Subjects fulfilling the following criteria will be eligible to participate in this study:
Definite diagnosis of MS;
Mild to moderate difficulty in ambulation with Expanded Disability Status Scale (EDSS) 2.0 – 5.0;
Able and agree to engage in maximal exercise test with minimal work load above 30 watts, which is the starting workload of graded incremental cycling test;
Able to walk independently;
Self-report in problem with fatigue;
Able to understand instructions and give informed consent
Inclusion criteria for healthy participants:
Healthy male or female
Over 18 years of age
The exclusion criteria include:
Use of medication prescribed for fatigue management (e.g Amantadine, Modafinil);
Currently participates in other clinical trials or exercise program;
Suffering from an exacerbation or relapse of MS within the past 3 months;
Severe depression;
Suffering form other neural, cardiovascular, orthopaedic or muscular disease besides MS;
Gastroesophageal disease or dysphagia which has difficulty in swallowing the disposable silicon-coated pill to measure core temperature;
Diverticulitis, which is a digestive disease could affect bowel and become contraindication to pill ingestion;
Subject who is known to be pregnant;
Subject with blood clotting problem prone to bleeding complications in blood lactate testing;
Known illness or infection
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method