Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 733
- 试验地点
- 1
- 主要终点
- Characterization of the natural and clinical histories of hereditary gastric cancer syndromes
研究概览
简要总结
Background:
Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers. They want to learn about changes these cause in the body and about the genes involved.
Objective:
-To gather data about hereditary gastric cancer.
Eligibility:
- People at least 2 years old with personal or family history with a hereditary gastric cancer.
- People at least 2 years old with gene changes that lead to such cancer or a lesion that may be hereditary.
Design:
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Participants will be screened in a separate protocol.
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Participants will have:
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Physical exam
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Medical history
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Blood tests
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Scans
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Photos of skin lesions and other findings
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Gynecology consultation for women
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Cheek swab (some participants)
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For some participants, their relatives will be asked to join the study.
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Some participants will be asked to allow the study to get stored tissue samples for relatives who have died.
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Some samples will be sent to outside labs. All personal data will be protected. Samples will be destroyed when the study ends.
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Participants will get the results of genetic testing.
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Participants who cannot come to the NIH clinic may just give a cheek swab and have genetic testing done.
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Some participants will be contacted for more testing.
详细描述
Background:
An estimated 1-3% of gastric cancer cases occur within a familial background as part of an inherited cancer syndrome.
Hereditary Diffuse Gastric Cancer (HDGC) is the most frequent form of familial gastric cancer and has been linked to a germline mutation in the CDH1 gene.
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) is a more recently described autosomal dominant syndrome characterized by fundic gland polyposis with antral sparing.
Other germline mutations that predispose to gastric cancer such as SDH (succinate dehydrogenase protein subunits) gene and CTNNA1 (alpha catenin).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •INCLUSION CRITERIA:
- •An individual, or their family members, with any of the following:
- •Fulfills clinical criteria for Hereditary Diffuse Gastric Cancer (HGDC) syndrome or Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) syndrome.
- •Clinically suspicious personal or family medical history of gastric cancer or gastric cancer syndrome that warrants genetics evaluation.
- •Current diagnosis of gastric cancer and a germline mutation associated with a known cancer syndrome or an associated family history of gastric cancer.
- •Harbors a pathogenic germline mutation known to predispose to gastric cancer.
- •First-degree relatives, regardless of family history or personal history of cancer, with a documented deleterious germline mutation (including but not limited to CDH1, CTNNA1, SDH) known to predispose to gastric tumors.
- •Diagnosis or suspicion of a premalignant or malignant stomach lesion of suspected hereditary etiology.
- •Age >= 2 years and older. Note: Patients under 18 years of age may only participate in research sample collection if the tissue acquisition is performed during a clinically indicated surgical procedure, and the sampling of tissue, blood, saliva or urine collection does not add risk to the clinically indicated procedures.
- •Ability of subject or legally authorized representative (LAR) to understand and the willingness to sign a written informed consent document.
排除标准
- 未提供
研究组 & 干预措施
Cohort 1
Subjects with suspicious personal or family medical history of gastric cancer or gastric cancer syndrome.
结局指标
主要结局
Characterization of the natural and clinical histories of hereditary gastric cancer syndromes
时间窗: 10 years
Characterization of the natural and clinical histories of hereditary gastric cancer syndromes
次要结局
未报告次要终点