Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

Completed

• Conditions: Enteral Nutrition; Critical Illness; Inflammation

• Registration Number: NCT03612206
• Lead Sponsor: Nanjing PLA General Hospital

Brief Summary

Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2018-03-01
• Study Completion: 2018-04-01
• Status Verified: 2018-07
• Study First Submitted: 2018-07-18
• Study First Submitted QC: 2018-07-27
• Last Update Submitted: 2018-07-27
• Study First Posted: 2018-08-02
• Last Update Posted: 2018-08-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 113

Inclusion Criteria

• initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission
• age more than 18 years
• Acute Physiology and Chronic Health Evaluation II (APACHE II) score >8

Exclusion Criteria

• not expected to survive 24 hours
• pregnancy
• any terminal stage disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28-day mortality	14 months	The number of survival and non-survival patients 28 days after inclusion
Intestinal barrier function within one week	14 months	The measurement of serum d-lactate was applied to evaluate the intestinal barrier function