NCT03612206已完成不适用
Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients
Nanjing PLA General Hospital0 个研究点目标入组 113 人开始时间: 2017年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 113
- 主要终点
- 28-day mortality
研究概览
简要总结
Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission
- •age more than 18 years
- •Acute Physiology and Chronic Health Evaluation II (APACHE II) score >8
排除标准
- •not expected to survive 24 hours
- •pregnancy
- •any terminal stage disease
结局指标
主要结局
28-day mortality
时间窗: 14 months
The number of survival and non-survival patients 28 days after inclusion
Intestinal barrier function within one week
时间窗: 14 months
The measurement of serum d-lactate was applied to evaluate the intestinal barrier function
次要结局
未报告次要终点
研究者
Gao Tao
Research Assistant
Nanjing PLA General Hospital
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