EUCTR2015-001562-26-GBActive, not recruitingNot Applicable
Preemptive paracetamol for postoperative pain: a randomised, double blind two way crossover trial - Preemptive paracetamol for postoperative pain
niversity of Nottingham0 sitesStarted: May 27, 2015Last updated:
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional clinical trial of medicinal product
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •Age 18-80 years old
- •Elective non-malignant cervical spinal surgery
- •Capacity to give informed consent
- •Ability to use PCA device and pain score scale
- •ASA I, II and III
- •General anaesthesia
- •>50kg in weight
- •Are the trial subjects under 18? no
- •Number of subjects for this age range: 0
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 25
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 25
Exclusion Criteria
- •Allergy or sensitivity to paracetamol, proparacetamol or morphine
- •Liver disease
- •Renal disease (creatinine clearance <30ml/min)
- •Bleeding disorder
- •Chronic alcoholism
- •Chronic malnutrition
- •Dehydration
- •G6PD deficiency
- •Hypernatraemia (Na >150)
- •Hypokalaemia (K <3.5) and hyperchloraemia
- •Pregnancy/breastfeeding
Investigators
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