Preemptive Paracetamol for Postoperative Pain: a Randomised, Double-blind, Two Way Crossover Trial
Overview
- Phase
- Phase 4
- Intervention
- Intravenous paracetamol
- Conditions
- Pain
- Sponsor
- University of Nottingham
- Enrollment
- 50
- Primary Endpoint
- Morphine consumption
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to test whether a dose of paracetamol given before surgical incision is more effective at reducing postoperative pain and analgesic consumption in cervical spine surgery versus a dose given at the end of surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Aged 18-80 years old
- •Patients listed for non-malignant cervical spinal surgery
- •General anaesthesia
- •Capacity to give informed consent
- •Ability to use PCA device and pain score scale
- •ASA I, II and III
- •\>50kg in weight
Exclusion Criteria
- •Allergy or sensitivity to paracetamol, proparacetamol or morphine
- •Liver disease
- •Renal disease (creatinine clearance \<30ml/min)
- •Bleeding disorder
- •Chronic alcoholism
- •Chronic malnutrition
- •Dehydration
- •G6PD deficiency
- •Hypernatraemia (Na \>150)
- •Hypokalaemia (K \<3.5) and hyperchloraemia
Arms & Interventions
Preemptive paracetamol
1000mg intravenous paracetamol given ≥15 minutes before surgical incision and intravenous saline 15 minutes before the end of surgery
Intervention: Intravenous paracetamol
Preemptive paracetamol
1000mg intravenous paracetamol given ≥15 minutes before surgical incision and intravenous saline 15 minutes before the end of surgery
Intervention: Intravenous saline 0.9%
Postincision paracetamol
Intravenous saline ≥15 minutes before surgical incision and 1000mg intravenous paracetamol given 15 minutes before the end of surgery
Intervention: Intravenous paracetamol
Postincision paracetamol
Intravenous saline ≥15 minutes before surgical incision and 1000mg intravenous paracetamol given 15 minutes before the end of surgery
Intervention: Intravenous saline 0.9%
Outcomes
Primary Outcomes
Morphine consumption
Time Frame: 24 hours postoperatively
Measured from PCA machine
Secondary Outcomes
- Time to first analgesic request(24 hours)
- Nausea and vomiting(24 hours)
- Pruritus(24 hours)
- Sedation(24 hours)
- Urinary retention(24 hours)
- Allergic reaction(24 hours)
- Pain score(24 hours)