Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy: a Randomized Control Trial
Overview
- Phase
- Phase 2
- Intervention
- Acetaminophen
- Conditions
- Post Operative Pain
- Sponsor
- Montefiore Medical Center
- Locations
- 1
- Primary Endpoint
- Post-operative opioid use
- Status
- Withdrawn
- Last Updated
- 3 years ago
Overview
Brief Summary
This study is investigating whether administration of acetaminophen the day before surgery improves post operative pain following minimally invasive hysterectomy. Patients will receive either acetaminophen or placebo to take twice per day the day prior to their scheduled surgery. The morning of surgery all participants will receive oral acetaminophen at least 30 minutes prior to surgery. The investigators will examine whether there is a difference in post operative pain between the two groups.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Undergoing minimally invasive hysterectomy for benign indications
Exclusion Criteria
- •acetaminophen allergy
- •liver disease
- •kidney disease
- •consume \>3 alcoholic beverages per day
- •weigh \<50 kilograms
- •report daily opiate use
- •contraindication to acetaminophen
- •used acetaminophen within 24 hours of surgery
- •undergoing a concomitant pelvic reconstructive procedure
Arms & Interventions
Preemptive acetominophen
Acetaminophen 975mg BID the day before surgery and again 30-60 minutes preoperatively
Intervention: Acetaminophen
Standard of care
Placebo the day before surgery and acetaminophen 30-60 minutes preoperatively
Intervention: Placebo
Outcomes
Primary Outcomes
Post-operative opioid use
Time Frame: 4 hours
The total amount of opiate consumption in the immediate postoperative period will be recorded. Per standard protocol, patient's will be ordered for pain medication to receive on an as needed basis. The amount of both oral and IV opioids consumed by the patient will be converted to total morphine equivalents. As such, post operative opioid use will be used as a proxy for degree of post operative pain.