Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Cherry concentrate; Dietary Supplement: Placebo concentrate

• Registration Number: NCT03547102
• Lead Sponsor: University of Exeter

Brief Summary

Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

Detailed Description

The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

Study Timeline

• Study Start: 2016-01
• Primary Completion: 2016-05
• Study Completion: 2016-12
• Study First Submitted: 2016-12-02
• Study First Submitted QC: 2018-05-23
• Status Verified: 2018-06
• Study First Posted: 2018-06-06
• Last Update Submitted: 2018-06-21
• Last Update Posted: 2018-06-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score >88

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Exclusion Criteria

• physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score <88 Contraindications for MRI

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cherry concentrate	Cherry concentrate	8 weeks supplementation with montmorency cherry concentrate
Placebo concentrate	Placebo concentrate	8 weeks supplementation with placebo isoenergetic cherry concentrate

Primary Outcome Measures

Name	Time	Method
Brain perfusion	Change from baseline to 8 weeks supplementation	Arterial spin labelling using MRI, measure will be reported as ml/min

Secondary Outcome Measures

Name	Time	Method
Brain activation (fMRI)	Change from baseline to 8 weeks supplementation	fMRI using a hippocampal biased task
Plasma nitrite concentration	Change from baseline to 8 weeks supplementation	Plasma sample analysed via chemiluminescence technique
Cognitive function	Change from baseline to 8 weeks supplementation	Battery of cognitive function tasks assessing executive function, global cognitive function score will be reported