The effect of whole-food dairy products on blood sugar regulation, bone health and feelings of hunger

Not Applicable

Completed

• Conditions: utritional study in healthy individuals; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN13531586
• Lead Sponsor: HAN University of Applied Sciences

Brief Summary

2023 Results article in https://doi.org/10.1016/j.tjnut.2023.12.012 (added 18/12/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-05-26
• Study Completion: 2022-10-19
• Last Update Posted: 8 January 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

1. Males and females
2. Age =20 and =40 years.
3. BMI =18.5 and =27.5 kg/m²

Exclusion Criteria

1. Blood donation during the study period
2. Currently smoking
3. Consumption of >21 alcoholic beverages per week
4. Use of illicit drugs
5. Regular use of protein or calcium supplements
6. A self-reported reported lactose intolerance, allergy or sensitivity to dairy ingredients
7. Reported slimming or medically prescribed diet
8. Use of antibiotics in the past month
9. Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, pulmonary disease, rheumatoid arthritis, orthopaedic disorders, renal disease, liver disease, diabetes mellitus, inflammatory disease, cognitive impairment, and thyroid or parathyroid disease)
10. Use of medications known to interfere with selected outcome measures (i.e. corticosteroids)
11. (Chronic) injuries of the locomotor system that can interfere with the intervention
12. Current participation in another biomedical research study
13. Trained individuals (i.e. performing sport activities for more than 6 hours per week)
14. Structural or competitively participating in exercise/sports with a substantial high-impact component, such as soccer, volleyball, running, and lower body resistance training

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postprandial kinetics and bioavailability of amino acids measured using blood samples at baseline, 15, 30, 45, 60, 90, 120, 180, 240, and 300 minutes

Secondary Outcome Measures

Name	Time	Method
1. Glycaemic response measured using blood samples (glucose, insulin, GLP-1) at baseline, 15, 30, 45, 60, 90, 120, 180, 240, and 300 minutes<br>2. Bone metabolism measured using blood samples (calcium, PTH, CTX, P1NP) at baseline, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes, and 24 hours<br>3. Feelings of hunger and satiety measured using the visual analogue score (VAS) baseline, 60, 120, 180, 240, and 300 minutes