Circulating cell free DNA: the fingerprint of the Placenta

• Conditions: Placental disease; 10035129

• Registration Number: NL-OMON56768
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

General:
- Pregnant women >= 18 years and <= 45 years who are willing to participate.
- Sufficient understanding of Dutch in speaking and reading.
- Willingness to give written informed consent.
- Singleton pregnancy.
- Blood drawing (venapunction) planned for clinical purposes.

Two patient groups are eligible:
- Healthy pregnant women with an uncomplicated pregnancy (10 controls).
- Healthy pregnant women with a premature delivery (between 24 and <37 weeks)
clinically with suspicion of inflammation (20 cases).

Placentas from the pathology archive that can be used for research for a
baseline quality check:
- 10 placentas from an uncomplicated pregnancy (controls)
- 10 placentas with a premature delivery (between 24 and <37 weeks) clinically
with suspicion of inflammation (cases)

Exclusion Criteria

Multiple pregnancy.
- Gastro-intestinal diseases, heart diseases, liver, pancreas and kidney
diseases.
- Pre-existent diabetes mellitus.
- Unable or unwilling to give informed consent.
- Fetus with a known congenital/chromosomal abnormality.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified