Circulating cell free DNA: the fingerprint of the Placenta
- Conditions
- Placental disease10035129
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 50
General:
- Pregnant women >= 18 years and <= 45 years who are willing to participate.
- Sufficient understanding of Dutch in speaking and reading.
- Willingness to give written informed consent.
- Singleton pregnancy.
- Blood drawing (venapunction) planned for clinical purposes.
Two patient groups are eligible:
- Healthy pregnant women with an uncomplicated pregnancy (10 controls).
- Healthy pregnant women with a premature delivery (between 24 and <37 weeks)
clinically with suspicion of inflammation (20 cases).
Placentas from the pathology archive that can be used for research for a
baseline quality check:
- 10 placentas from an uncomplicated pregnancy (controls)
- 10 placentas with a premature delivery (between 24 and <37 weeks) clinically
with suspicion of inflammation (cases)
Multiple pregnancy.
- Gastro-intestinal diseases, heart diseases, liver, pancreas and kidney
diseases.
- Pre-existent diabetes mellitus.
- Unable or unwilling to give informed consent.
- Fetus with a known congenital/chromosomal abnormality.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method