The Effect of prethrombolytic Cyclosporine A injection on Acute Anterior ST-Elevation Myocardial Infarction Outcome.
- Conditions
- Acute myocardial infarction.Acute transmural myocardial infarction of anterior wall
- Registration Number
- IRCT138807052474N2
- Lead Sponsor
- Research vice-chancellor of Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion criteria : in patients with 18 years of age or older, presence of ischemic chest pain and ST segment elevation of 1 mm or more in at least two contiguous leads of anterior region, who admits in primary six hours of symptoms onset and candidate for thrombolytic therapy
Exclusion criteria : cardiac arrest, primary VF, prior MI, uncontrolled HTN, known hypersensitivity to cyclosporine, known renal failure or a serum creatinine level of 120 mol per liter (1.36 mg per deciliter) or more at admission, liver failure, and women who were pregnant or who were of childbearing age and were not using contraception, any disorder that is associated with immunologic dysfunction e.g., cancer, lymphoma, a positive serologic test for the human immunodeficiency virus, or hepatitis
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method VEF. Timepoint: 1st day & predischarge. Method of measurement: echocardiography.;Incidence of Heart Failure. Timepoint: During admission. Method of measurement: Basal pulmonary rales , lasix using, chest XRAY.;Incidence of Arrhythmia. Timepoint: During admission. Method of measurement: ECG monitoring.
- Secondary Outcome Measures
Name Time Method All cause mortality rate. Timepoint: in hospital & 6 month later. Method of measurement: patient documents & calling.