Systemic cyclosporine administration for high-risk corneal transplantatio
Phase 4
- Conditions
- High-risk corneal transplantation
- Registration Number
- JPRN-UMIN000003767
- Lead Sponsor
- Tokyo Dental College, Ichikawa General Hospital
- Brief Summary
1. There was no obvious effect in systemic cyclosporine administration for prevention of rejection in patients with high-risk corneal transplantation. 2. Since approximately one-fourth of patients discontinued cyclosporine due to systemic side effects, the use of the drug is not recommended especially for elderly patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1) poorly controlled diabetes mellitus 2) poorly controlled hypertension 3) abnormal kidney function 4) abnormal liver function 5) active ocular infection 6) active systemic infectious diseases 7) uncontrollable ocular hypertension 8) severe corneal limbal dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of graft rejection following corneal transplantation
- Secondary Outcome Measures
Name Time Method Incidence and severity of local or systemic complications