Effects of Viral Reactivation on Outcomes of Brain-injured Patients ( IBIS-VIRUS)
- Conditions
- Brain Injury
- Registration Number
- NCT02003196
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
Morbidity and mortality of ICU patients is increased by the development of a "immunosuppression" systemic (IS). This IS develops in the early hours of hospitalization and is responsible for severe infections, including viral reactivations (Cytomegalovirus or Herpes Simplex Virus). Viral reactivation was associated with increased morbidity and mortality in intensive care units. In clinical practice, they are searched at the onset of organ failure or unexplained fever. The investigators wish to conduct this research in the stroke patients to assess the predictive power of these viral reactivations on the duration of mechanical ventilation.
- Detailed Description
PCR for herpes simplex virus in blood and in tracheal aspirate (Day-1, Day-7 and Day-15) - clinicians are blinded to the results PCR for Cytomegalovirus in blood and in tracheal aspirate (Day-1, Day-7 and Day-15) - clinicians are blinded to the results
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 375
- Hospitalisation in intensive care unit
- Acute brain injury (trauma, subarachnoid haemorrhage, stroke, infection) with Glasgow Coma Scale <= 12
- Age between 18 and 75 years
- Mechanical ventilation > 24 hours
- encephalopathy post anoxy
- active cancer
- Immunosuppresseur treatment
- pregnancy
- history of autoimmune disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ventilatory-free days at day 90 90 days
- Secondary Outcome Measures
Name Time Method Bacterial hospital acquiered infection 28 days organ failure 28 days hospitalisation length of stay 28 days Mortality 28 days and 90 days
Trial Locations
- Locations (1)
CHU de Nantes
🇫🇷Nantes, France