Effects of Viral Reactivation on Outcomes of Brain-injured Patients ( IBIS-VIRUS)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 375
- 试验地点
- 1
- 主要终点
- Ventilatory-free days at day 90
研究概览
简要总结
Morbidity and mortality of ICU patients is increased by the development of a "immunosuppression" systemic (IS). This IS develops in the early hours of hospitalization and is responsible for severe infections, including viral reactivations (Cytomegalovirus or Herpes Simplex Virus). Viral reactivation was associated with increased morbidity and mortality in intensive care units. In clinical practice, they are searched at the onset of organ failure or unexplained fever. The investigators wish to conduct this research in the stroke patients to assess the predictive power of these viral reactivations on the duration of mechanical ventilation.
详细描述
PCR for herpes simplex virus in blood and in tracheal aspirate (Day-1, Day-7 and Day-15) - clinicians are blinded to the results PCR for Cytomegalovirus in blood and in tracheal aspirate (Day-1, Day-7 and Day-15) - clinicians are blinded to the results
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalisation in intensive care unit
- •Acute brain injury (trauma, subarachnoid haemorrhage, stroke, infection) with Glasgow Coma Scale <= 12
- •Age between 18 and 75 years
- •Mechanical ventilation > 24 hours
排除标准
- •encephalopathy post anoxy
- •active cancer
- •Immunosuppresseur treatment
- •pregnancy
- •history of autoimmune disease
结局指标
主要结局
Ventilatory-free days at day 90
时间窗: 90 days
次要结局
- Bacterial hospital acquiered infection(28 days)
- organ failure(28 days)
- hospitalisation length of stay(28 days)
- Mortality(28 days and 90 days)