The Regulation of Pulmonary Vascular Resistance in Patients With Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
Peripheral blood and blood following a pulmonary wedge pressure will be obtained from patients undergoing right heart catheterizations.
详细描述
It is well known that left sided heart disease can lead to pulmonary hypertension via a number of proposed mechanisms. The purpose in this study is to identify biomarkers in pulmonary hypertension to further understand the pathophysiology of this disease in patients with heart disease.Patients are recruited in the cardiac catheterization lab, which are undergoing right heart catheterization as per their plan of care established by their primary cardiologist. During the procedure, we will ask the performing cardiologist to obtain a blood sample of 40-50 milliliters from the catheter that they are using during the procedure. These blood samples will be sent for analysis of biomarkers. The patient will then have an echocardiogram done 1 year from their heart catheterization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 years
- •Ability to provide informed consent.
- •Presenting for cardiac catheterization for evaluation of heart disease
- •Ejection Fraction > 50%
排除标准
- •Unable to provide informed consent.
- •Unable or unwilling to comply with the protocol and follow up.
- •Infiltrative cardiomyopathy
- •Constrictive pericarditis
- •Severe valvular disease
- •Comorbid status with life expectancy <3 years
- •Right ventricular dysplasia
- •Congenital heart disease
- •On immunosuppressive drugs.
- •Patients who has heart transplant.
- •Ejection Fraction < 50%
- •Mean Pulmonary Artery Pressure <25
- •Wedge pressure <15
结局指标
主要结局
Mortality
时间窗: 1 year
Checking vital statistics on each patient at one year
次要结局
- Morbidity(1 year)