Biomarkers in Samples From Younger Patients With Wilms Tumor
- Conditions
- Wilms Tumor and Other Childhood Kidney Tumors
- Interventions
- Other: laboratory biomarker analysis
- Registration Number
- NCT01493817
- Lead Sponsor
- Children's Oncology Group
- Brief Summary
This research study is studying biomarkers in tissue samples from younger patients with Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment
- Detailed Description
PRIMARY OBJECTIVES:
I. To determine whether recruitment of tumor-associated macrophages is related to clinicopathological factors in Wilms tumor (tumor stage, presence of vascular invasion, tumor progression, and survival).
OUTLINE:
Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Wilms tissue microarray samples provided by the Children's Oncology Group
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Basic science (biomarker analysis) laboratory biomarker analysis Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.
- Primary Outcome Measures
Name Time Method Relationship of tumor-associated macrophages and prognosis 1 month Correlation of each type of macrophage score with tumor staging, presence of vascular invasion, and disease-free survival will be assessed.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Oncology Group
🇺🇸Monrovia, California, United States