Perioperative Neuroprotection of Stellate Ganglion Block
- Conditions
- Intracranial Aneurysm
- Interventions
- Drug: Stellate Ganglion Block
- Registration Number
- NCT02275247
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Brief Summary
To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery
- Detailed Description
The vasospasm after cranial aneurysm surgery have a higher incidence, but not have an ideal treatment method. At present, the medical treatment is very limited effect to prevent the perioperative cerebral ischemia.Stellate ganglion block （SGB）is an effective and well-tolerated approach to the treatment of CVS in various clinical settings.Resent study indicated that SGB has a protective effect on delayed cerebral vasospasm in an experimental rat model of subarachnoid hemorrhage.Therefore,we hypothesized that the preoperative SGB would be a effective treatment for improvement of vasospasm after cranial aneurysm surgery.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
- aneurysm subarachnoid hemorrhage patients scheduled for cranial aneurysm surgery，
- ASA grade：Ⅱ-Ⅲ，
- Hunt～Hess grade :Ⅰ-Ⅲ,
- have a informed consent.
- history of mental illness，
- local infection who can't do stellate ganglion block，
- pregnant or lactating，
- nausea cancer or diabetes，
- participated the study or other related research in the last 30 days，
- unruptured aneurysms patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Intervention 'Stellate Ganglion Block' Stellate Ganglion Block Experimental patients will receive a stellate ganglion block with 0.25% ropivacaine 6-8mL on the right side at the level of the sixth cervical vertebrae (C6) before surgery.Then the catheter will be attached to a single use patient-controlled analgesia pump containing 0.2% ropivacaine 150 mL, which will be infused at 2 mL/h.
- Primary Outcome Measures
Name Time Method The incidence of cerebral vasospasm Change from baseline at 2hour,6hour,1day,3day,and 7day after aneurysm surgery The occurrence of cerebral vasospasm will be diagnosed by using of the transcranial doppler instrument.
- Secondary Outcome Measures
Name Time Method Perioperative cerebral oxygen metabolism Change from baseline at 2hour,6hour,1day,3day,and 7day postoperatively Cerebral oxygen metabolism will be monitored through jugular venous oxygen saturation (SjVO2) and cerebral extraction rate of oxygen (CERO2), and measured by blood gas analysis at each time point, the latter will be calculated using the formula:
CaO2 = (Hb\*1.38\*SaO2) + (0.003\*PaO2); CvO2 = (Hb\*1.38\*SjvO2) + (0.003\*PjvO2); CERO2 = (CaO2-CvO2)/CaO2 where CaO2 is arterial oxygen content, Hb is arterial hemoglobin concentration, SaO2 is arterial oxygen saturation, PaO2 is the arterial partial pressure of oxygen, CvO2 is mixed venous oxygen content and PjvO2 is the jugular venous partial pressure of oxygen.The difference of plasma endothelin, melatonin, and S100-β protein level between two groups at each time point Change from baseline at 2hour,6hour,1day,3day,and 7day postoperatively A 5-mL jugular venous blood sample will be taken at each time point, centrifuged at 3,000 rpm for 25 min, and kept in a freezer at -80°C until analysis. the concentrations of plasma endothelin, melatonin, and S100-β protein will be measured using enzyme-linked immunosorbent assays.
Postoperative cognitive function Change from baseline at 2hour,6hour,1day,3day,and 7day after aneurysm surgery The postoperative cognitive function will be measured by using of the mini-mental state examination (MMSE).
Trial Locations
- Locations (1)
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China