CTRI/2025/03/083103尚未招募2 期
Effect of SGLT2 Inhibitors on Renal Resistive Index in Diabetic Nephropathy Patients : A Quasi-Experimental Study
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 148
- 试验地点
- 1
- 主要终点
- SGLT2 inhibitors ( T.DAPAGLIFOZIN 10mg once daily) contribute to a significant reduction in renal resistive index and urine albumin creatinine ratio , suggesting their potential as a therapeutic option for slowing the progression of diabetic nephropathy
研究概览
简要总结
My study aimed to evaluate the effect of SGLT2 inhibitors on renal resistive index and urine acr.
Patients will receive SGLT2 inhibitor therapy for 3 months , after which the measurements were reassessed to determine changes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •includes patients with Type 2 diabetes mellitus whose Blood pressure is controlled that is within 140/90mmHg , urine albumin creatinine ratio within 300 , estmated glomerular filtration rate more than 60ml/min/1.73 meter square and patient treated with other oral antihyperglycemic agents other than SGLT2 inhibitors.
排除标准
- •includes patients with obstructive uropathy , co existent renal pathologies or anomalies , on nephrotoxic drugs , patients with refractory hypertension , patients already on SGLT2 inhibitors and insulin , patients with severe hepatic insufficiency , recurrent urinary tract infection , peripheral vascular disease , fever , infection , menstruating females and excluding females who are within 7 days pre and post menstrual cycle.
结局指标
主要结局
SGLT2 inhibitors ( T.DAPAGLIFOZIN 10mg once daily) contribute to a significant reduction in renal resistive index and urine albumin creatinine ratio , suggesting their potential as a therapeutic option for slowing the progression of diabetic nephropathy
时间窗: Primary outcome assessed at 3 months following the start of the drug(T.DAPAGLIFOZIN 10mg once daily)
次要结局
- Renal resistive index can detect(diabetic nephropathy much earlier than urine Albumin Creatinine Ratio.)
研究者
Chandni Jayakumar
SRM Medical College Hospital and Research Centre
研究点 (1)
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