Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension

Not Applicable

Recruiting

• Conditions: Sepsis; Post Induction Hypotension
• Interventions: Drug: Noradrenaline 0.1 microgram/kg/minute infusion

• Registration Number: NCT07022730
• Lead Sponsor: Cairo University

Brief Summary

researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension

Detailed Description

If post-induction hypotension is not addressed promptly, it can lead to severe complications such as reduced blood flow, acute kidney damage, and myocardial ischemia. As a result, early detection and proactive intervention are crucial. Researchers of the current study decided to investigate impact of noradrenaline administered as a prophylaxis on post induction hypotension

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-06-07
• Study First Submitted QC: 2025-06-07
• Study First Posted: 2025-06-15
• Study Start: 2025-06-22
• Last Update Submitted: 2025-06-22
• Last Update Posted: 2025-06-26
• Primary Completion: 2025-10-30
• Study Completion: 2025-11-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Adult patients with sepsis undergoing source control surgery.

Exclusion Criteria

• Patient refusal
• Patient with cardiac pathology ( ischemic heart disease or heart failure)
• Preoperative hemodynamic instability (defined as MAP < 65 mmHg)
• Rapid sequence induction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Noradrenaline	Noradrenaline 0.1 microgram/kg/minute infusion	Noradrenaline will be infused at a fixed rate of 0.1 mic/kg/min at 5 minutes before induction

Primary Outcome Measures

Name	Time	Method
Incidence of post induction hypotension in both groups	Within the first 20 minutes of induction.	Hypotension will be considered if MAP\< 65 mmHg

Secondary Outcome Measures

Name	Time	Method
Incidence of acute kidney injury	7 days post operative	defined as the highest postoperative value \> 1.5-fold or 0.3 mg/dL greater than the preoperative value
Incidence of myocardial infarction	7 days postoperative	defined as a peak troponin T value exceeding 15 times the normal upper limit, along with new pathological Q waves, ST elevation or depression, and hyperacute T wave on ECG and symptoms suggestive of myocardial infarction
Incidence of stroke	7 days postoperative	clinical or image finding of stroke

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Cairo Governorate, Egypt