Secondary Prevention in Type 2 Diabetes: Comparison of Two Different Resistance Exercise Training Protocols

Phase 1

Completed

• Conditions: Type 2 Diabetes Mellitus
• Interventions: Other: Physical exercise training

• Registration Number: NCT01218256
• Lead Sponsor: Paracelsus Medical University

Brief Summary

Skeletal muscle accounts for up to 40% of the total body weight and is responsible for approximately 75% of the whole body insulin-stimulated glucose uptake. Resistance training has been shown to improve insulin-stimulated glucose uptake in patients with T2DM. Therefore the investigators aim to compose the effects of 2 different resistance training protocols in combination with aerobic endurance training (AET) on muscle strength, muscle mass and glycemic control in type 2 diabetes mellitus patients (T2DM).

The investigators aim to perform an 8 week randomized controlled training intervention in 32 T2DM patients. Patients will be randomly assigned to AET (cycle ergometer, 60-70% of heart rate reserve) combined with hypertrophy resistance training (HRT, n=16, 2 sets, 10-12 repetitions, 70% of the one-repetition maximum) or with endurance resistance training (ERT, n=16, 2 sets, 25-30 repetitions, 40% of the one-repetition maximum). Body composition, blood analyses, physical work capacity and muscle strength will be measured pre- and post-intervention.

Detailed Description

Not available

Study Timeline

• Status Verified: 2007-06
• Study Start: 2007-07
• Primary Completion: 2008-12
• Study Completion: 2009-05
• Study First Submitted: 2010-10-08
• Study First Submitted QC: 2010-10-08
• Last Update Submitted: 2010-10-08
• Study First Posted: 2010-10-11
• Last Update Posted: 2010-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• type 2 diabetes mellitus

Exclusion Criteria

• myocardial infarction within the last 6 months
• unstable angina pectoris
• left ventricular ejection fraction less than 40%
• orthopedic limitations that eliminate to perform resistance training

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hypertrophy resistance training	Physical exercise training	Aerobic endurance training combined with hypertrophy resistance training in type 2 diabetes mellitus.
Endurance resistance training	Physical exercise training	Aerobic endurance training combined with hypertrophy resistance training in type 2 diabetes mellitus.

Primary Outcome Measures

Name	Time	Method
Muscle strength	8 weeks	Measruement will be performed using Concept Dyno 2

Secondary Outcome Measures

Name	Time	Method
Muscle mass	8 weeks	Muscle mass will be measured using dual X-ray absorbiotometry
Glycemic control	8 weeks	Fasting blood glucose, HbA1c, and fructosamin will be measured using routine laboratory methods

Trial Locations

Locations (1)

Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University; 🇦🇹 Salzburg, Austria