A study of proteins involved in the inflammation and pain associated with osteoarthritis of the knee

Not Applicable

• Conditions: Osteoarthritis(OA) of the knee; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12609001007224
• Lead Sponsor: Royal Perth Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-11-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

*primary knee osteoarthritis (OA), which has been diagnosed based on clinical and radiographic criteria, according to the American College of Rheumatology(knee pain,either age > 50 or morning stiffness < 30 mins or crepitus, osteophytes)
*With radiographic evidence of OA for the studied knee based on retrospective bilateral radiography (within last 12 months): Anterior-posterior view in extension and weight bearing position and sky-line view”; radiographic changes defined by Kellgren-Lawrence score (I to V)
*Moderately severe symptoms (> or =40/100 on pain Visual Analogue Scale)
*Aged more than 18 years
*Able to provide written informed consent

Exclusion Criteria

*Contraindication or unwillingness to undergo an Ultrasound scan
*Contraindication or unwillingness to undergo arthrocentesis(including an International normalised ratio greater than 2.0 in subjects on warfarin, or patients on therapeutic dose heparin/ Low Molecular Weight heparin)
*Diagnosis of septic arthritis, inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis
*With secondary OA, as defined by The Group for the Respect of Ethics and Excellence in Science: septic arthritis, inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis
*With injury to the study knee within 6 months of the study start
*With a knee joint replacement (partial or total); osteotomy of the studied joint; with arthroscopy of the studied joint made within 1 year of the study start
*With an intra articular injection of steroids made within 4 weeks and/or intra articular injection of radionuclide made with 3 months prior to study entry

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine by light and confocal immunocytochemistry, the expression of kallikreins, kininogens, and kinin receptors on neutrophils harvested from the circulation and synovial fluid of patients with OA[cross sectional (N/A)]

Secondary Outcome Measures

Name	Time	Method
To determine whether expression of kallikreins, kininogens, and kinin receptors on neutrophils harvested from synovial fluid correlates with joint disease in patients with OA, as determined by Ultrasound and clinical symptoms[cross sectional (N/A)];To determine if expression and localization of kallikreins, kininogens, and kinin receptors in patients with OA correlates with joint disease in patients with OA, as determined by Ultrasound and clinical symptoms[cross sectional (N/A)]