Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest
- Registration Number
- NCT00676585
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Brief Summary
The major goal of this project is to determine whether the use of physiologic doses of corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and alters microcirculatory flow in post-cardiac arrest patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Greater than 18 years old
- Either pre-hospital cardiac arrest and ROSC or Inpatient Cardiac Arrest with resultant ROSC
- Vasopressor dependent for a minimum of 1 hour post-arrest
Exclusion Criteria
- Pregnant
- Indication for Corticosteroids outside of current research proposal
- DNR or comfort care measures
- Presence of septic shock
- Chronic Use (>1week) of oral Corticosteroids in the last year
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Hydrocortisone Hydrocortisone 100mg every 8 hours. 2 Normal Saline Normal Saline
- Primary Outcome Measures
Name Time Method Time to Shock Reversal 7 Days The primary outcome was time to shock reversal defined as at least 24 hours off all vasopressor medications.
- Secondary Outcome Measures
Name Time Method Mortality Length of hospital stay, an average of 9 days with a maximum of 36 days Sub-group Analysis of Patients With Adrenal Insufficiency At time of enrollment Sub-analysis of patients with adrenal insufficiency: absolute insufficiency as defined by a baseline cortisol level \< 15 ug/dL
Trial Locations
- Locations (1)
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States