Replacement of Vitamin D in Women with Breast Cancer Who Will Undergo Chemotherapy Before Surgery
Not Applicable
Recruiting
- Conditions
- Malignant neoplasms (tumors) of the breast
- Registration Number
- RBR-10k4gqdg
- Lead Sponsor
- niversidade Estadual Paulista - Unesp
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
Women aged above 45 years with a recent histological diagnosis of breast cancer, eligible for neoadjuvant chemotherapy (presence of luminal tumors A or B with clinically positive armpit; luminal tumor B larger than three centimeters; triple negative tumor; tumor Human Epidermal growth factor Receptor-type 2 positive, pure or hybrid, stage III)
Exclusion Criteria
Vitamina d supplementation women with breast carcinoma in situ, previous history of other cancers, chronic kidney disease (creatinine upper 1.4 milligrams/deciliter), liver disease, alcohol or drug addiction will be excluded
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome will be to assess the complete tumor pathological response rate of women with breast cancer undergoing vitamin D supplementation during neoadjuvant chemotherapy. The present study was based on previous research by Almeida-Filho (2017), who detected hypovitaminosis D in 66.1% of women at the time of breast cancer diagnosis and only 33.9% with sufficient values of vitamin D, in women attended at the mastology service of the Botucatu Medical School - São Paulo State University
- Secondary Outcome Measures
Name Time Method Secondary outcome will be to evaluate the complete tumor pathological response rate of women with breast cancer undergoing vitamin D supplementation during neoadjuvant chemotherapy according to age group; tumor staging and subtype; anthropometry (obesity and waist circumference); presence of metabolic syndrome; baseline serum values of vitamin D; and the vitamin D receptor polymorphism