Circulating Tumor Cells as a Biomarker for Preoperative Prognostic Staging in Patients With Esophageal Cancer

Completed

• Conditions: Resectable Esophageal Cancer
• Interventions: Procedure: esophagectomy

• Registration Number: NCT01858805
• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Brief Summary

Despite the availability of several preoperative diagnostic techniques, accurate pretreatment staging of esophageal cancer (EC) remains challenging. Therefore, The investigators evaluated the prognostic significance of circulating tumor cells (CTCs) in patients with EC.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2013-05-14
• Study First Submitted QC: 2013-05-16
• Study First Posted: 2013-05-21
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-17
• Last Update Posted: 2014-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 123

Inclusion Criteria

• > 18 years
• resectable esophageal cancer

Exclusion Criteria

• < 18 years
• esophageal cancer with preoperative distant metastases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
detection of circulating tumors cells	esophagectomy	This prospective, single-institution study conducted at the University Hospital Hamburg-Eppendorf (Hamburg, Germany) enrolled 123 patients with ECs that were initially considered resectable. Only patients with histologically proven EC were included. Peripheral blood samples for CTC analysis were collected immediately before surgery.

Primary Outcome Measures

Name	Time	Method
overall survival	2 years

Secondary Outcome Measures

Name	Time	Method
recurrence-free survival	2 years

Trial Locations

Locations (1)

University Hospital Hamburg-Eppendorf; 🇩🇪 Hamburg, Germany