Noninvasive Monitoring in Lower Body Negative and Positive Pressure Tests

Not Applicable

Completed

• Conditions: Hemorrhage
• Interventions: Device: Fluid shift

• Registration Number: NCT03671902
• Lead Sponsor: Dartmouth-Hitchcock Medical Center

Brief Summary

The goal of these studies is to assess the use of phonocardiograhy to monitor blood volume. We will evaluate phonocardiographic parameters in normal subjects in increasing levels of lower body negative pressure (LBNP) and lower body positive pressure (LBPP).

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-01
• Primary Completion: 2018-03-30
• Study Completion: 2018-03-30
• Study First Submitted: 2018-09-13
• Study First Submitted QC: 2018-09-13
• Study First Posted: 2018-09-14
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-21
• Last Update Posted: 2023-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• At least 18 years old
• Good health
• Free of systemic diseases
• No contraindications to LBNP/LBPP exposure
• Normal resting systolic blood pressure (SBP, 100-140 mm Hg) and diastolic blood pressure (DBP, 60-90 mm Hg)

Exclusion Criteria

• Pregnancy
• Prior history of cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Lower Body Negative/Positive Pressure	Fluid shift	-

Primary Outcome Measures

Name	Time	Method
Change in the phonocardiographic systolic index (PSI)	Baseline, and at each incremental change of 5-10 mmHg up to 40 mm Hg. Total duration per arm is up to 45 min	Measuring changes in phonocardiographic parameters related to changes in blood volume

Trial Locations

Locations (1)

Dartmouth-Hitchcock Medical Center; 🇺🇸 Lebanon, New Hampshire, United States