Articulatory Adaptation Following Oral Cancer Treatment

Recruiting

• Conditions: Speech Disorders; Oral Cavity Squamous Cell Carcinoma
• Interventions: Other: Electromagnetic Articulography

• Registration Number: NCT05876247
• Lead Sponsor: University Medical Center Groningen

Brief Summary

The goal of this longitudinal study is to learn more about the articulatory consequences of surgical oral cancer treatment. The main aims are to study the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or tactile information can predict the success of speech compensatory strategies.

Participants will perform multiple speech tasks while motion tracking sensors track the articulatory gestures.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-10
• Status Verified: 2023-05
• Study First Submitted: 2023-05-16
• Study First Submitted QC: 2023-05-16
• Study First Posted: 2023-05-25
• Last Update Submitted: 2023-05-25
• Last Update Posted: 2023-05-30
• Primary Completion: 2024-08
• Study Completion: 2025-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Diagnosed with T1 or T2 tumor in the oral cavity
2. At least 18 years old and able to provide informed consent
3. Native speaker of Dutch
4. Has nog been treated for oral cancer before

Exclusion Criteria

1a. Recurrence of disease (for patients)

1b. Treated for oral cancer (for healthy controls) 2. Speech problems (e.g., stuttering) 3. Problems with sight or hearing that impede reading or understanding instructions. When glasses or a hearing aid resolve these problems, then participants are not excluded.

4. Neurological or psychological disorders (e.g., stroke) 5. Non-removable metal in, on or around the head (piercings, braces, pacemaker, electrodes) 6. Self-reported signs of depression

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Individuals treated for oral cancer	Electromagnetic Articulography	Dutch native speakers (18+) who will undergo surgical treatment for a T1 or T2 tumour on the tongue.
Control speakers	Electromagnetic Articulography	Dutch native speakers (18+) without self-reported speech problems.

Primary Outcome Measures

Name	Time	Method
Articulatory gestures	2022-2025	Articulatory movements in three dimensions of the tongue, lips and jaw as measured by the NDI Vox Electromagnetic Articulograph. Measures include: articulator speed (mm/s), total displacement (mm), coordinates (x,y,z) during specific gestures.
Acoustic outcomes	2022-2025	Speech acoustics will be measured in Praat and include the first and second formants of vowels (in Hz), global movement size in terms of acoustic working space (Hz-squared), and the centre of gravity of sibilants (in Hz)

Trial Locations

Locations (2)

Faculty of Arts, University of Groningen; 🇳🇱 Groningen, Netherlands

University Medical Centre Groningen; 🇳🇱 Groningen, Netherlands