A randomised controlled trial investigating the effects of compression stockings in patients who require blood thinning medication post discharge from elective surgery

Not Applicable

• Conditions: Venous thromboembolism; Circulatory System

• Registration Number: ISRCTN11667770
• Lead Sponsor: Imperial College London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-18
• Last Update Posted: 29 April 2024
• Study Completion: 2026-09-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 8608

Inclusion Criteria

1. Adults (>18 years)
2. Participants undergoing elective surgery; risk assessed as requiring EDPTP. Participants are deemed to require extended duration thromboprophylaxis measures as per local policy in line with NICE [NG89] guidelines. Examples of procedures from which patients are at the highest risk of VTE include (but are not limited to): orthopaedic surgery (total hip replacement, total knee replacement, colorectal surgery (colectomy, splenectomy), upper gastrointestinal surgery (oesophagectomy, gastrectomy), urological surgery (cystectomy, nephrectomy), and gynaecological oncology surgery (radical hysterectomy, radical trachelectomy).

Exclusion Criteria

1. Contraindications to EDPTP or GCS
2. Individuals requiring therapeutic anticoagulation e.g., anticoagulation for previous DVT
3. Known thrombophilia or thrombogenic disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Imaging-confirmed lower limb DVT with or without symptoms, or PE with symptoms, occurring up to 90 days post-surgery

Secondary Outcome Measures

Name	Time	Method
Defined as occurring within 90 days of surgery:<br>1. Mortality recorded within 90 days<br>2. Adverse events related to GCS recorded within 90 days<br>3. Adherence with GCS, defined as (percentage of actual days worn / maximum number of days prescribed according to local practice)<br>4. Adherence with EDPTP, defined as (percentage of actual days taken / maximum number of days prescribed, according to local practice)<br>5. Safety outcome measures, defined as major bleeding events recorded within 90 days