Demonstration research on platform construction of intervention of phlegm and blood stasis by TCM internal and external treatment

Not Applicable

Recruiting

• Conditions: Dyslipidemia

• Registration Number: ITMCTR1900002590
• Lead Sponsor: The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Non-spleen deficiency turbid non-hyperlipidemia group inclusion criteria:
1. Non-dyslipidemia: Adult fasting 12 hours serum TC < 5.2mmol/L (200mg/dl), TG <1.7mmol/L (150mg/dl), LDL-C <3.4mmol/L (130mg/dl), HDL-C>1.0 mmol/L (40 mg/dl);
2. TCM diagnosis did not reach the diagnostic criteria for spleen deficiency, phlegm and spleen deficiency syndrome;
3. Aged 18 to 75 years old;
4. Volunteer to participate in the trial and sign the informed consent form.
Dyslipidemia patients enrolled in the standard1 Western medicine meets the diagnostic criteria for dyslipidemia:
1. Adult fasting 12 hours serum TC >=5.2mmol/L (200mg/dl) or TG >=1.7mmol/L (150mg/dl), or LDL-C >=3.4 mmol/L (130mg / dl Or HDL-C <1.0 mmol/L (40 mg/dl). TC is a mandatory item;
2. medical history for more than three months;
3. Chinese medicine meets the diagnostic criteria of spleen-qi deficiency syndrome or spleen deficiency and phlegm syndrome;
4. Aged 18 to 75 years old;
5. Volunteer to participate in the trial and sign the informed consent form.

Exclusion Criteria

1. Subjects with acute myocardial infarction, cerebrovascular accident, severe trauma or major surgery within six months;
2. Secondary hyperlipidemia: Hyperlipidemia caused by nephrotic syndrome, hypothyroidism, gout, acute or chronic hepatobiliary diseases, and diabetes;
3. Family hereditary dyslipidemia;
4. Hyperlipidemia caused by drugs (phenothiazines, beta-blockers, adrenocortical steroids and certain contraceptives, etc.);
5. Heparin, thyroxine therapeutics, and other subjects who are affecting lipid metabolism drugs are being used;
6. Take antibiotics within 2 months before sampling, take microbial live bacteria preparations (including yogurt) within 1 week before sampling, and take statin lipid-lowering drugs 2 weeks before sampling;
7. Consolidation of subjects with severe primary diseases such as liver, kidney, and hematopoietic system.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood lipid;Intestinal flora;Intestinal flora pathway protein;

Secondary Outcome Measures

Name	Time	Method
ipid metabolism related protein;