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临床试验/CTRI/2026/03/106514
CTRI/2026/03/106514尚未招募4 期

TRAMADOL HYDROCHLORIDE WITH ADRENALINE AN ALTERNATIVE LOCAL ANESTHESTIC FOR EXTRACTION OF MANDIBULAR TEETH A DOUBLE BLINDED PROSPECTIVE INTERVENTIONAL STUDY

Dr JAI SWEDHA SELF1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2026年3月24日最近更新:
适应症

试验速览

阶段
4 期
状态
尚未招募
发起方
入组人数
30
试验地点
1
主要终点
• Enhanced Anesthestic duration

研究概览

简要总结

Local Anesthesia plays a crucial role in Oral and Maxillofacial surgery, ensuring patient comfort during procedures such as tooth extraction and other oral surgical procedures. Lidocaine, an amide type anesthetic , has been the gold standard due to its rapid onset, effectiveness and safety profile. However , alternative anesthetics like tramadol have gained attention for their potential local anesthetic properties , particularly in patients who are allergic to conventional agents.

Tramadol , a centrally acting opioid , has demonstrated local anesthetic properties. Several studies have compared the efficacy of tramadol versus lidocaine for dental procedures. But the mechanism on how it causes anesthetic effect is not fully understood .It has been found that Tramadol with adrenaline can be used as an alternative to lidocaine with adrenaline in terms of onset of anesthesia , duration of anesthesia , pain score via local infiltration technique .There are not enough literature to prove its effect as a nerve block  and for any procedure in mandible .This study evaluates the efficacy of Tramadol hydrochloride with adrenaline for inferior alveolar nerve block for intra alveolar extraction of mandibular posterior teeth

研究设计

研究类型
Interventional
分配方式
Na
盲法
None

入排标准

年龄范围
18.00 Day(s) 至 45.00 Day(s)(—)
性别
All

入选标准

  • • Patients both males and females aged 20 – 45 years.
  • • Patients indicated for extraction of mandibular teeth • ASA-I physical status patients • Patients willing to participate in the study.

排除标准

  • Impacted mandibular 3rd molars Pregnant or lactating females, Patients with a history of drug allergy Patients not willing to participate in the study Patients with trismus (mouth opening less than 30 mm).

结局指标

主要结局

• Enhanced Anesthestic duration

时间窗: • Lower post operative analgesic consumption | • Enhanced Anesthestic duration | • Reduced Intraoperative pain

• Reduced Intraoperative pain

时间窗: • Lower post operative analgesic consumption | • Enhanced Anesthestic duration | • Reduced Intraoperative pain

次要结局

  • Lower post operative analgesic consumption(NIL)

研究者

发起方
Dr JAI SWEDHA SELF
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

DR JAI SWEDHA B

Sri Ramachandra Institute of Higher Education and Research

研究点 (1)

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