Randomized, double blind, placebo controlled clinical study to evaluate oftopical ibuprofen gel for the inhibition of bone loss in chronic periodontitis.
Phase 2
- Conditions
- Periodontal diseases.Periodontal diseases
- Registration Number
- IRCT2014050517587N1
- Lead Sponsor
- Deputy of Research Council Of Dental Branch, Islamic Azad University of Tehran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
Inclusion Criteria: Systemically healthy patients with chronic periodontitis with periodontal pockets 4 millimeters deep or more at the both sides of posterior teeth in Mandibular Jaw.
Exclusion Criteria
Existing systemic disease; Pregnancy; Lactation; Smokers; Patients who had taken any kind of medication during the previous six months; No periodontal treatment the previous six months; Hypersensitive to Ibuprofen; Orthodontic treatment; Cancer and Chemotherapy; Numerous large caries; The use of any mouthwash during the study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pocket depth. Timepoint: 15 Days. Method of measurement: Periodontal Probe.;Bleeding on probing. Timepoint: 15. Method of measurement: Periodontal Probe.
- Secondary Outcome Measures
Name Time Method Increased alveolar bone density. Timepoint: 3 months. Method of measurement: Bone densitometer machine.;Reduction of plaque index. Timepoint: 3 Months. Method of measurement: Loe & Silness Index.