Effect of combined use of two drugs dexamethasone and dexmedetomidine on duration of nerve block
Not Applicable
- Conditions
- Health Condition 1: M958- Other specified acquired deformities of musculoskeletal system
- Registration Number
- CTRI/2020/11/029153
- Lead Sponsor
- SRI manakula vinayagar medical college hospital RESEARCH FUND
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients who are scheduled for upper limb fracture (elbow, forearm) fixation surgery
Patients with American Society of Anesthesiologists Physical Status Classification (ASA) I and II of age 18-70 years belonging to both genders
Exclusion Criteria
Chronic pain disorder
Pregnancy
Refusal to participate in the study
History of cardiac, renal, hepatic disease
History of uncontrolled diabetes mellitus
Preexisting neurological deficits or neuropathy affecting the brachial plexus
Contraindications to peripheral nerve block (coagulopathy, block needle site infection)
Allergy or hypersensitivity to local anesthetics.
Block failure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare time to first analgesic requirement in all 4 groups (control group, IV dexamethasone group, IV dexmedetomidine group, Combined IV dexamethasone and IV dexmedetomidine group)Timepoint: 24-48 hours
- Secondary Outcome Measures
Name Time Method Duration of motor blockade <br/ ><br>Duration of sensory blockade <br/ ><br>1.Pain severity at 6, 12, 18 and 24 h postoperatively using VAS score <br/ ><br>2.Cumulative postoperative tramadol and paracetamol dose used in 24 hours <br/ ><br>3.Dexmedetomidine related side effects (hypotension, bradycardia and sedation), <br/ ><br>4.Dexamethasone related side effects (increasing blood sugar, perineal pruritus, surgical site infection and delayed wound healing). <br/ ><br>Timepoint: 24-48 hours