Childhood study on respiratory pathogens from induced sputum
Recruiting
- Conditions
- 'lower respiratory tract infections''lung infection'10024970
- Registration Number
- NL-OMON35654
- Lead Sponsor
- Jeroen Bosch Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Tachypnea combined with at least one of: elevated body temperature, cough, dyspnea or abdominal pain
Exclusion Criteria
- Acute exacerbation of asthma in the last 4 weeks. This is defined as requiring systemic coricosteroids, hospital admission and/or use of ß-sympaticomimetics >400 µg per day
- Oxygen saturation < 92% without oxygen therapy or severely ill impression
- Anatomical abnormalities of the respiratory tract presenting with inspiratory stridor
- Use of β-blockers, diuretics or theophylline
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The quality of induced sputum, defined as <25 squamous cells and >25 leukocytes<br /><br>per visual field under light microscopy.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To identify bacterial and viral pathogens of lower respiratory tract infections.<br /><br><br /><br>To determine the practical applicability of sputum induction in general<br /><br>pediatric practice.<br /><br><br /><br>To determine the prevalence of Coxiella burnetii infections (Q fever) in<br /><br>children with lower respiratory tract infections.<br /><br><br /><br>To determine the prevalence of Influenza A type H1N1-infections in children<br /><br>with lower respiratory tract infections.</p><br>