ong-term use of antipsychotics for behavioral symptoms in patients with mental retardation; a controlled discontinuation study.

Completed

• Conditions: mental retardation; antipsychotics; discontinuation; behavioral symptoms

• Registration Number: NL-OMON22173
• Lead Sponsor: Gerda de Kuijper

Brief Summary

se of antipsychotic drugs in individuals with intellectual disability: prevalence and reasons for prescription. (Gerda de Kuijper, Pieter J Hoekstra, Frank Visser, Frans Scholte†, Corine Penning, Heleen Evenhuis Journal of Intellectual Disability Research 2010;54:659-67). <br><br> Effects of controlled discontinuation of long-term used antipsychotics for behavioural symptoms in individuals with intellectual disability. (Gerda de Kuijper, Heleen Evenhuis, Ruud Minderaa, Pieter J. Hoekstra Journal of Intellectual Disability Research , accepted for publication, 2012, Epub).<br><br> Determinants of physical health parameters in individuals with intellectual disability who use long-term antipsychotics. (Gerda de Kuijper, Hans Mulder, Heleen Evenhuis, Frans Scholte †, Frank Visser, Pieter J. Hoekstra Research in Developmental Disabilities, accepted for publication, 2013). Effects of controlled discontinuation of long-term used antipsychotics on weight and metabolic parameters in individuals with intellectual disability. (Gerda de Kuijper, Hans Mulder, Heleen Evenhuis, Frank Scholte †, Frank Visser, Pieter J. Hoekstra Journal of Clinical Psychopharmacoloy, august 2013). <br><br> Effects of controlled discontinuation of long-term used antipsychotics on prolactin and bone turnover markers in patients with intellectual disability. (Gerda de Kuijper, Hans Mulder, Frans Scholte †, Frank Visser, Heleen Evenhuis, Pieter J. Hoekstra Journal of Clinical Psychopharmacoloy, accepted for publication, 2013).

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

1. Intellectually disabled persons (i.e., functioning at an IQ below 70);

2. aged between 15-65 year;

Exclusion Criteria

1. A history of schizophrenia, a bipolar disorder, or affective psychosis according to DSM IV criteria;

2. a history of unsuccessful withdrawal of antipsychotics in the past 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aberrant Behavior Checklist.

Secondary Outcome Measures

Name	Time	Method
1. Weight;<br /> <br>2. middle-circumference;<br /> <br>3. glucose metabolism;<br /><br>4. lipid metabolism;<br /> <br>5. bone metabolism;<br /> <br>6. autonomic symptoms;<br /> <br>7. signs of tardive dyskinesia and tardive akathisia.