Evaluation effect of Indomethacin for Covid19 infectio

Phase 2

Recruiting

Conditions: Pneumonia induced by covid19.
COVID-19, virus identified
U07.1

Registration Number: IRCT20200427047215N1

Lead Sponsor: Isfahan University of Medical Sciences Vice Chancellor for Research and Technology

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Patients 18 to 75 years old hospitalized
Patient with SpO2:85-89% on room air at admission (if correct with nasal O2 maximum 6 liter/min to SpO2>=90 )
Patients with SpO2: 90-93% and RR>=30
clinical compatible patients with positive RT-PCR test or consistent HRCT to covid19 pneumonia
Sign the study participation form

Exclusion Criteria

Known hypersensitivity to indomethacin or any components of NSAIDs
History of asthma, urticarial, or other allergic type reaction after taking aspirin or NSAIDs
GFR less than 60ml/minute/1.7m2
Patients with active gastrointestinal bleeding
The need for intubation in the first 24 hours of hospitalization
Patients with multi organ failure
Patients with shock state at admission
Pregnant woman
Lactating woman
Patients with active peptic ulcer
Consumption of NSAID on admission

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to clinical recovery. Timepoint: Control clinical signs daily until discharge from the hospital. Method of measurement: Fever control with thermometer, oxygen saturation control with pulsoximetry.;14 days readmission after discharge. Timepoint: Up to 14 days after discharge. Method of measurement: All patients will be given a contact number to notify them if they are hospitalized again. All patients will be monitored by phone weekly for up to 4 weeks after the first day they are admitted.;Time to intubation. Timepoint: Control of oxygen saturation, respiratory status every 6 hours during hospitalization. Method of measurement: If the patient needs intubation due to reduced oxygen saturation or increased respiration rate, the date of incubation will be recorded on a daily basis from the time of hospitalization.

Secondary Outcome Measures

Name	Time	Method
Survival 28 days after hospitalization. Timepoint: From the first day of hospitalization to 28 days after hospitalization. Method of measurement: A questionnaire is used to measure survival. At the time of hospitalization, this questionnaire is completed daily by one of the researchers. After discharge, the patient's condition will be monitored weekly for up to 4 weeks after the first day of hospitalization.