The effect of intrathecal morphine in reducing intraoperative and postoperative pain in patients undergoing laparoscopic hysterectomy
Phase 4
Completed
- Conditions
- Health Condition 1: null- Patients undergoing total laparoscopic hystrectomy under general anaesthesia
- Registration Number
- CTRI/2015/11/006370
- Lead Sponsor
- All india institute of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 47
Inclusion Criteria
ASA I or ASA II patients undergoing laparoscopic hysterectomy
Exclusion Criteria
•Inability to provide informed consent
• Refusal for spinal anaesthesia
•Morbid obesity
•Coagulation disorders or treatment with anticoagulants
•Severe spinal deformities
•Infection at the injection site
•Symptomatic cardiac and respiratory disease
•Chronic analgesic use
•Not capable of understanding PCA device use
•Undergoing concurrent laparoscopic procedures
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To determine the efficacy of intrathecal morphine for perioperative analgesia <br/ ><br>in patients undergoing total laparoscopic hysterectomy by its effect on VAS. <br/ ><br>2. To assess the effect of intrathecal morphine on perioperative endocrine <br/ ><br>stress markers compared with fentanyl infusion.Timepoint: 1.The first pain assessment was done as soon as <br/ ><br>the patient was awake, oriented and capable of following commands. VAS scoring was done 2-hourly for 8 hours and at 24 hours. <br/ ><br>2.Blood samples for stress markers were taken 8 a.m one day prior to surgery , half an hour after initiation of pneumoperitoneum and one hour after the end of surgery.
- Secondary Outcome Measures
Name Time Method 1. To assess perioperative opioid sparing effect of intrathecal morphineTimepoint: 24 hours