SHMT1 Polymorphism in Parkinson's Disease,

• Conditions: Study the Role of SHMT1 Polymorphism in Parkinson Disease
• Interventions: Genetic: SHMT1 polymorphism

• Registration Number: NCT04706065
• Lead Sponsor: Assiut University

Brief Summary

Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system . SHMT has been shown to be associated with various diseases.

Detailed Description

This case -control observational prospective study will conducted on 40 patients with PD.

Study Timeline

• Study First Submitted: 2021-01-03
• Study First Submitted QC: 2021-01-09
• Study First Posted: 2021-01-12
• Study Start: 2021-01-31
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-30
• Last Update Posted: 2021-06-02
• Primary Completion: 2021-07
• Study Completion: 2022-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients age ≥ 50 years.
• Patients with PD diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UK PDS Brain Bank diagnostic criteria)

Exclusion Criteria

• Patients with parkinsonian plus syndrome

  • Patients with secondary parkinsonism
  • Patients with other chronic comorbidities (renal, hepatic, and endocrinal disturbances and chronic chest disease.)
  • Past and /or present history of epilepsy.
  • Patients with disturbed conscious level.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 2	SHMT1 polymorphism	Group 2 (controls) All participants will be subjected to thorough history taking, full clinical and neurological examination.
GROUP 1	SHMT1 polymorphism	Group 1 (patients with PD) All participants will be subjected to thorough history taking, full clinical and neurological examination. Diagnosis of PD by using Brain Bank Criteria for diagnosis of Parkinson Disease , assessment of the severity of PD by using PDRS and evaluation of cognitive functions using MMSE.

Primary Outcome Measures

Name	Time	Method
polymorphism of SHMT1gene	one year

Secondary Outcome Measures

Name	Time	Method
the role of SHMT1plymorphism in pathogenesis PD	one year
Study the relationship of Shmt1 polymorphism to the severity of Parkinson disease	One year

Trial Locations

Locations (1)

Effat abdelhady tony; 🇪🇬 Assuit, Egypt