Evaluation of 41 Cases of Pediatric Granuloma Annulare

Completed

• Conditions: Granuloma Annulare

• Registration Number: NCT05472636
• Lead Sponsor: Istanbul Training and Research Hospital

Brief Summary

INTRODUCTION: Granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. Although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. It is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study.

MATERIALS and METHODS: This study was performed retrospectively in a single-center, tertiary dermatology hospital. Forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Demographic characteristics, and clinical and histopathological features were evaluated.

Detailed Description

Granuloma annulare; is a non-infectious, granulomatous skin reaction with potential triggers that can affect the adult and pediatric age group. Diabetes mellitus, hyperlipidemia, and malignancy have been described in association with adult granuloma annulare cases. While there are studies on the clinical, pathological features and associated diseases in patients with adult granuloma annulare, a limited number of studies have been conducted on pediatric granuloma annulare patients. Therefore, clinical and histopathological evaluation of pediatric granuloma annulare cases was planned in our study.

This study was performed retrospectively in a single-center tertiary dermatology hospital. Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Cases with uncertain diagnosis were not included in the study. Cases with dermatological findings recorded in detail and/or diagnosed histopathologically were included in the study. Demographic features, lesion localization, lesion characteristics (size, elementary lesion, color), involvement (localized/generalized), histopathological features, concomitant diseases, differential diagnoses in cases with histopathology, regression time and recommended treatments were recorded.

Study Timeline

• Study Start: 2022-03-11
• Primary Completion: 2022-05-11
• Study Completion: 2022-06-01
• Status Verified: 2022-07
• Study First Submitted: 2022-07-15
• Study First Submitted QC: 2022-07-21
• Last Update Submitted: 2022-07-21
• Study First Posted: 2022-07-25
• Last Update Posted: 2022-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Being under 18 years old
• Having granuloma annulare
• Applying to the Istanbul Training and Research Hospital, Dermatology Outpatient Clinic between 2008-2021
• Consenting to participate in the study

Exclusion Criteria

-Being over 18 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of the ages of the pediatric patients with granuloma annulare	day 0	age (year)
Histopathological evaluation of the infiltration type of the pediatric patients with granuloma annulare	day 0	neutrophilic, lymphocytic, lymphohistiocytic, eosinophil, mixed infiltrations
Histopathological evaluation of the infiltration pattern of the pediatric patients with granuloma annulare	day 0	Interstitial, palisadic
Evaluation of epidermal findings	day 0	regular/irregular, hyperkeratosis, acanthosis
Evaluation of the genders of the pediatric patients with granuloma annulare	day 0	male, female
Evaluation of the lesion type of the pediatric patients with granuloma annulare	day 0	papule, pustule, plaque, nodule
Evaluation of the lesion duration of the pediatric patients with granuloma annulare	day 0	the time interval in between appearance of the lesion and diagnosis (month)
Evaluation of the clinical involvement	day 0	localized, generalized
Evaluation of the concomitant diseases of the pediatric patients with granuloma annulare	day 0	the concomitant diseases of the participants
Evaluation of the lesion localization of the pediatric patients with granuloma annulare	day 0	head and neck, upper extremity, lower extremity, trunk
Evaluation of the mean size of the lesion	day 0	diameter (cm)
Evaluation of depth of infiltrate	day 0	superficial, medium, deep

Trial Locations

Locations (1)

Istanbul Training and Research Hospital; 🇹🇷 Istanbul, Turkey