Nerve Growth Factor in Chronic Pancreatitis
Completed
- Conditions
- Chronic Pancreatitis
- Registration Number
- NCT01255917
- Lead Sponsor
- Virginia Commonwealth University
- Brief Summary
This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis.
Hypothesis:
1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is not only a mechanical problem
2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is variably expressed in different morphological stages of CP and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 38
Inclusion Criteria
- Patients with established CP and none of the exclusion criteria mention below.
Exclusion Criteria
- Failure to obtain consent.
- Any comorbid condition with expected survival < 1 year.
- Patients with pacemaker, implanted metallic prosthesis or other contraindications to do MRCP.
- Patients < 18 years of age at time of consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The levels of NGF in subjects with different morphological stages of chronic pancreatitis (CP) will be compared to the controls and in each morphological stage of CP will be correlated with pain scores. 5 years
- Secondary Outcome Measures
Name Time Method Correlate the expression of NGF and other inflammatory cytokines in the pancreatic juice in each morphological stage of CP. 5 years
Trial Locations
- Locations (1)
Virginia Commonwealth University Medical Center
🇺🇸Richmond, Virginia, United States