The effect of vitamin D3 administration in endometrium of patients with recurrent implantion failure
Phase 2
- Conditions
- Repeated implantation failure.
- Registration Number
- IRCT20220528055006N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 24
Inclusion Criteria
Regular menstruation (25-35 days)
Not using vitamin D3 for 3 months before endometrial biopsy
Not using hormonal contraceptive methods and IUD for 3 months before biopsy
Age under forty
A history of three failures in embryo implantation after IVF or ICSI following the transfer of the A quality embryos
Infertility without a specific cause
Exclusion Criteria
Active autoimmune disease
Hormonal disorders
Thrombophilia
Uterine anatomical problems such as myoma, fibroid, polyp, intrauterine adhesions or congenital disorders of the uterus.
Endometriosis and polycystic ovarian syndrome
Hydrosalpinx
Infertility with male factors
Vitamin D3 consumption in the last three months
Age over forty
Genetic and chromosomal disorders in each couple
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Women with recurrent implantation failure. Timepoint: Measuring blood vitamin D levels in two groups, measuring blood vitamin D levels in the clinical trial group after taking oral vitamin D And before starting the ART cycle. Method of measurement: Examining the serum level of vitamin D using a blood test, measuring the expression level of VDR, IGFB-P1, PR, PRL and HOXA10 genes in endometrial samples using Quantitative Reverse Transcription Polymerase Chain Reaction, measuring the level of IGFB-P1, PR, PRL and HOXA10 in endometrial samples using immunohistochemistry.
- Secondary Outcome Measures
Name Time Method