Efficacy of oral pyridostigmine for the treatment of acute colonic pseudo-obstruction - a prospective, randomized, placebo-controlled trial.
Phase 2
- Conditions
- Acute colonic pseudo-obstructionOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12621000254897
- Lead Sponsor
- Eastern Health - Box Hill Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Adult patients with acute colonic pseudo-obstruction confirmed on imaging (plain abdominal radiograph, computed tomography, or magnetic resonance imaging) in whom a distal colonic obstruction has been ruled out via a rigid sigmoidoscopy.
Exclusion Criteria
Patients with known adverse reaction to pyridostigmine.
Patients with signs of abdominal peritonism.
Patients currently already on oral pyridostigmine.
Patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Passage of bowel motions, as sighted and documented on stool chart by ward nursing staff.[48 hours post commencement of intervention.]
- Secondary Outcome Measures
Name Time Method Time to passage of flatus, as reported by the patient, to the ward nursing staff. [48 hours post commencement of intervention.]