Dietary Practices and Metabolic Syndrome in the Young Adult Population of Rwanda

Completed

• Conditions: Nutritional Status; Metabolic Syndrome; Diet Habit
• Interventions: Other: Dietary habits; Other: Risk factors associated with metabolic syndrome

• Registration Number: NCT04204538
• Lead Sponsor: University Ghent

Brief Summary

Policy makers in Rwanda have recently highlighted the importance of promoting healthy diets and lifestyle in response to rapidly increasing rates of obesity. This project will provide evidence on shifts in diet and nutritional status in urban dwellers as compared to the traditional diet and lifestyle in rural areas as a basis for a targeted public health policy for Rwanda.

Detailed Description

Adequate diet has been known for many years to be a major lever to significantly decrease the risk for non-communicable diseases (NCD). However, mainly due to urbanization and improved economic status in low and middle income countries (LMICs), the traditional largely plant-based diets are being replaced by more energy-dense and nutrient poor diets, incorporating more animal foods and processed foods and fat, and with a decrease in consumption of fruits and vegetables and other plant based foods. This diet change together with a sedentary lifestyle are typical phenomena in LMICs that are driving the so-called nutrition transition that is typically accompanied by an increase in obesity and in NCD like metabolic syndrome, diabetes, cardiovascular diseases and cancer. In Rwanda, NCD lead to 36% of total deaths. Cancers, diabetes, cardiovascular diseases, and chronic respiratory diseases account for 82% of NCD deaths. The major risk factor is the raised blood pressure (34.4%) and the probability of dying between ages 30 and 70 years from those four main NCD is estimated to 19%.

The Government of Rwanda has installed an operational NCD unit in the Ministry of Health with a view to developing preventive strategies vis-à-vis the nutrition transition process in the country. It has been shown already that there is a need for adopting dietary behaviour change to prevent the epidemic of chronic diseases.

The aim of this PhD work is to contribute in generating evidence needed to develop targeted prevention strategies for NCD in a broader framework of informed health policy making in Rwanda.

Specific objectives:

1. To identify the changes in eating habits of different socio- economic subgroups in adults living in Kigali, in comparison to their peers in rural areas;

2. To assess nutritional status and body composition using several methods (BMI, skinfold thicknesses, sitting height and body build, fat and fat free mass), with the ultimate objective to establish population-body composition-derived BMI cut-offs for overweight and obesity in this population;

3. To assess and compare the prevalence of common risk factors for non-communicable disease (high BMI, low fruit and vegetable consumption, low physical activity and high blood pressure) between rural and urban areas;

4. To evaluate people's nutrition knowledge, aptitude and capacity (KAP), perception of obesity and normal weight and food insecurity levels as risks factors for adherence to healthy dietary practices and life style;

5. To generate information to be used by governments to improve dietary habits and physical activity through targeted interventions.

The data collected in a cross sectional study design. Validated questionnaires will be used to get information on socio-economic characteristics, dietary practices, physical activity, other lifestyle factors and psycho-social and emotional indicators.

Study Timeline

• Study First Submitted: 2019-11-27
• Study First Submitted QC: 2019-12-16
• Study First Posted: 2019-12-19
• Study Start: 2021-11-01
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-06
• Last Update Posted: 2024-02-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1247

Inclusion Criteria

• Permanent residence of the selected urban or rural villages
• Holding a valid health insurance card
• Aged between 18 and 35 years
• Signing informed consent form
• Registration in city demographic system, since study participants will be selected from population registration cards at village level,
• Accept enumerators for home visit and data collection
• Accept to visit the laboratory for blood sample collection,
• Not suffering from any chronic disease such as VIH/ AIDS, diabetes, asthma, etc.

Exclusion Criteria

• Lactating, pregnant, and recently delivering (less than six month-postpartum) women
• Physical disabilities that can prevent participants from working
• Mental disability such as clinically diagnosed depression, anxiety disorders, eating disorders and addictive behaviors.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Urban	Risk factors associated with metabolic syndrome	Young adults living in urban communities of Rwanda
Rural	Dietary habits	Young adults living in rural communities of Rwanda
Urban	Dietary habits	Young adults living in urban communities of Rwanda
Rural	Risk factors associated with metabolic syndrome	Young adults living in rural communities of Rwanda

Primary Outcome Measures

Name	Time	Method
Prevalence of high triglyceride concentrations	Through study completion (an average of 6 months)	High triglyceride level \[\>150 milligrams per deciliter (mg/dL)\]
Prevalence of large waist circumference	Through study completion (an average of 6 months)	Large waist circumference \[\> 89 centimeters for women and \>102 centimeters for men\]
Prevalence of high levels of fasting blood sugar	Through study completion (an average of 6 months)	Elevated fasting blood sugar \[\>100 mg/dL\]
Prevalence of high-density lipoprotein (HDL) cholesterol	Through study completion (an average of 6 months)	Reduced high-density lipoprotein (HDL) cholesterol \[\< 40 mg/dL in men or \< 50 mg/dL in women\]
Prevalence of participants with nutrition knowledge	Through study completion (an average of 6 months)	Nutritional knowledge of macronutrients, micronutrients, water intake, diet and disease will be collected using a multiple choice answers. Each question had one mark for every correct response chosen. Using a marking scheme for nutritional knowledge test the scores were rated on score percentages using eight cut off points, with scores less than 20% indicating a bad nutritional knowledge, 50-59% satisfactory and Excellent for those scoring 80% and more.
Prevalence of the different dietary patterns	Through study completion (an average of 6 months)	Dietary patterns will be identified using exploratory factor analysis on the food groups collected using the semi-quantitative Food Frequency Questionnaire. The dietary pattern identified will differ from plant_based diet and legume_based diet to western diet.
Prevalence of high blood pressure	Through study completion (an average of 6 months)	Increased blood pressure \[\> 130/85 mm Hg\]

Secondary Outcome Measures

Name	Time	Method
Prevalence of Food Insecure Households	Through study completion (an average of 6 months)	The Household Food Insecurity Access (HFIA) Score is a continuous measure of the degree of food insecurity in the household and is based on a set of questions that encompass three domains of food insecurity: (1) anxiety and uncertainty about the household food supply; (2) insufficient quality; and (3) insufficient food intake and its physical consequences (Coates et al. 2007).; Each household receives a score from 0-27 based on a simple sum of the frequency of occurrence of each food insecurity condition, where 'never' = 0 points, 'rarely' = 1 point, 'sometimes' = 2 points, and 'often' = 3 points. The higher the score, the higher the degree of household food insecurity experienced in the previous four weeks.

Trial Locations

Locations (1)

University of Rwanda; 🇷🇼 Kigali, Rwanda