Improving Individual Glycemic Response With Exercise Intensity
- Conditions
- PreDiabetesExerciseDiabetes Mellitus, Type 2Physical Activity
- Interventions
- Behavioral: Maintained ExerciseBehavioral: Increased Intensity
- Registration Number
- NCT03787836
- Lead Sponsor
- University of New Brunswick
- Brief Summary
Large interindividual variability exists in the glycemic response to exercise program, resulting in a subset of individuals known as exercise non-responders (NRs). Increasing the intensity of an exercise intervention has been proposed as one method for rescuing NRs by producing beneficial changes. However, this theory has not been tested on NRs classified using glycemic outcomes. This study will evaluate if increasing the intensity of an exercise intervention will elicit a response within previous exercise NRs.
- Detailed Description
Exercise can effectively slow the progression towards Type 2 diabetes (T2D). However, data suggest large interindividual variability exists in glycemic response to exercise, resulting in a subset of individuals known as exercise non-responders (NRs). Emerging research proposes that altering the parameters of an exercise intervention to provide a sufficient stimulus can elicit a response in those previously identified as NRs. To date, no research has attempted to rescue previously classified NRs based on glycemic outcomes by altering the parameters of an exercise intervention.
This study will implement an exercise program targeted at achieving the Canadian Physical Activity Guidelines, and calculate the number of NRs. We will then evaluate if increasing the intensity of exercise will elicit response to the treatment in the NRs.
Sixty adults living with prediabetes or T2D will be recruited into one of a control group, or an exercise group. The exercising participants will begin a 16-week exercise intervention, targeted at achieving 150 minutes of moderate to vigorous intensity (equating to 4.5 METs) aerobic physical activity per week. Following the 16-week exercise program, participants will be randomized into two groups, each completing an additional 12 weeks of exercise. The first will maintain the same time and intensity, while the other will complete the 150 minutes per week at an intensity equal to 6.0 METs. Randomization will occur in blocks in order to ensure an equal number of NRs in each group.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 61
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercisers (Maintained) Maintained Exercise The maintained exercise group will complete the original 16-week exercise intervention at an intensity of 4.5 metabolic equivalents (METs), and repeat the intervention for another 12-weeks following its completion. Exercisers (Increased Intensity) Increased Intensity The increased intensity exercise group will complete the original 16-week exercise intervention, followed by an additional 12 week intervention completed at an intensity of 6.0 METs.
- Primary Outcome Measures
Name Time Method Exercise responders following additional exercise program Week 30 The number of responders following the additional 12-week exercise program, based on improvement in glycated hemoglobin
Exercise responders following initial program Week 17 The number of responders to the original 16-week exercise program, based on improvement in glycated hemoglobin
- Secondary Outcome Measures
Name Time Method Height Baseline, week 17 and week 30 Height (centimetres)
Body mass Baseline, week 17 and week 30 Body mass (kilograms)
Current medication use Baseline Record of quantity and dose of current medications
Family history of cardiovascular disease Baseline Self-reported family history of cardiovascular disease
Daily step count Baseline Daily step count as recorded over a 7-day period
Family history of cardiometabolic disease Baseline Self-reported family history of cardiometabolic disease
Physical activity patterns Baseline Participant self-reported physical activity patterns and daily step counts over a 7-day period.
Waist circumference Baseline, week 17 and week 30 Waist circumference (cm)
Fat mass Baseline, week 17 and week 30 Fat mass (kg)
Fat free mass Baseline, week 17 and week 30 Fat free mass (kg)
Sex Baseline Participant self-reported biological sex
Cardiorespiratory fitness Baseline, week 17 and week 30 VO2 peak
Body mass index Baseline, week 17, week 30 Weight (kilograms) and height (measured in centimetres and converted to metres) will be combined to report body mass index in kg/m\^2
Trial Locations
- Locations (1)
University of New Brunswick
🇨🇦Fredericton, New Brunswick, Canada