The Benefits of Early Initiation of Continuous Renal Replacement Therapy (CRRT) in Patients With Severe Sepsis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 主要终点
- mortality
研究概览
简要总结
The study will evaluate the benefit of early initiation of CRRT in the initial phase of severe sepsis in patients admitted to the ICU. Primary evaluated end-point is 28-day mortality. Secondarily evaluated end-point is length of ICU-stay, length of stay in hospital, duration of mechanical ventilation. There are two groups. One group of participants with early CRRT initiation and another group with late CRRT initiation. Reference group no CRRT.
详细描述
The aim is to determine the optimal timing of initiation of CRRT with respect to the degree and duration of acute kidney injury (AKI) in ICU patients. The CRRT parameters and the duration of therapy will be monitored, depending on initial biochemical and clinical values of the patient. Part of the study is the follow-up of patients with a 3-month delay.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •reaching criteria of severe sepsis, ICU admission
排除标准
- •pregnant women, younger than 18 years, reaching contraindications for initiation of renal replacement therapy
结局指标
主要结局
mortality
时间窗: 28 days
yes/no
次要结局
- duration of mechanical ventilation(28 days)
研究者
Radovan Uvizl
MUDr.
University Hospital Olomouc