EUCTR2009-013228-21-GB进行中（未招募）不适用
Prevention of atrial oxidative stress and electrical remodelling in patients undergoing cardiac surgery: randomised placebo-controlled trial of perioperative high-dose atorvastatin - Do statins prevent atrial rhythm disturbances after cardiac surgery?
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Patients who are:
- •1. Willing and able to give informed consent for participation in the study
- •2. In normal sinus rhythm at the time of surgery
- •3. Stable and requiring elective cardiac surgery.
- •4. Able (in the Investigators’ opinion) and willing to comply with all study requirements.
- •5. Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •?Age>80yrs
- •? Female participant who is pregnant, lactating or planning pregnancy during the
- •course of the study.
- •? Women of child-bearing potential without appropriate contraceptive measures. These
- •include oral contraceptive pills, Intrauterine contraceptive devices etc
- •? History of obstructive hepatobiliary disease or other serious hepatic disease or preoperative ALT >2-fold the upper limit of normal or alcohol abuse
- •? Creatinine >200 umol/L
- •? Untreated hypothyroidism
- •? Family history of hereditary muscle disorders
- •? Known intolerance to statins or history of muscle toxicity with fibrates or statins.
- •? Ongoing use of fibrates, niacin or of agents that are strong inhibitors of cytochrome
- •P-450 or the P-glycoprotein within a month preceding randomization (cyclosporine,
- •azole antifungals, such as itraconazole and ketoconazole, macrolide antibiotics, such
- •as erythromycin and clarithromycin, protease inhibitors, nefazodone, verapamil,
- •amiodarone or large quantity of grapefruit juice (= 1L/day) Patients on treatment with anti arrhythmic agents, other than beta-adrenergic receptor blockers.
- •? Participant who is terminally ill or is inappropriate for placebo medication.
研究者
相似试验
进行中（未招募）
1 期
Preventing Systemic Inflammation after Cardiac surgery with Alkaline Phosphatase (APPIRED III)systemic inflammation as side-effect of heart-lung machine during cardiac surgeryMedDRA version: 20.0 Level: LLT Classification code 10017501 Term: Functional disturbances following cardiac surgery System Organ Class: 100000004863EUCTR2016-002663-33-BEAlloksys Life Sciences BV1,250
进行中（未招募）
1 期
Preventing Systemic Inflammation after Cardiac surgery by Alkaline Phosphatase (APPIRED III)systemic inflammation as side-effect of heart-lung machine during cardiac surgeryMedDRA version: 20.0 Level: LLT Classification code 10017501 Term: Functional disturbances following cardiac surgery System Organ Class: 100000004863MedDRA version: 20.0 Level: LLT Classification code 10062357 Term: SIRS System Organ Class: 100000004867EUCTR2016-002663-33-NLAlloksys Life Sciences BV1,250
进行中（未招募）
1 期
Preventing Systemic Inflammation after Cardiac surgery with Alkaline Phosphatase (APPIRED III)systemic inflammation as side-effect of heart-lung machine during cardiac surgeryMedDRA version: 20.0Level: LLTClassification code 10017501Term: Functional disturbances following cardiac surgerySystem Organ Class: 10022117 - Injury, poisoning and procedural complicationsEUCTR2016-002663-33-ATAlloksys Life Sciences BV1,250
招募中
3 期
Preventing Oxidative stress-induced ischemic injury and systemic inflammation complications during and after invasive cardiac surgery with Alkaline Phosphatase (APPIRED III)renal failureNL-OMON49105Alloksys Life Sciences BV150
尚未招募
不适用
Effect of hyperoxia in pediatric patient via oxygen reserve index monitoringskull bone malformationMusculoskletal malformationanesthesiologyMusculoskeletal - Other muscular and skeletal disordersACTRN12620000553976Marmara University Medical Faculty20