A Prospective Comparative Evaluation Of The Effect Of Folliculinum Vs Constitutional Homoeopathic Medicine In Cases Of PCOS, Assessed By The FSH/LH Ratio

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often associated with menstrual irregularities, hyperandrogenism, and altered FSH/LH ratio. This prospective, randomized, comparative study aims to evaluate the effect of Folliculinum versus individualized constitutional homeopathic medicines on hormonal balance in women with PCOS. A total of 50 female patients, aged 18–40 years, diagnosed according to Rotterdam criteria and not on hormonal treatment for at least 3 months, will be enrolled. Participants will be randomly allocated into two groups: one receiving Folliculinum and the other receiving the individualized constitutional remedy, both for 12 months. The primary outcome is the change in serum FSH/LH ratio from baseline to 12 months. Secondary outcomes include menstrual regularity, hirsutism (Ferriman-Gallwey score), acne severity (GAG score), emotional health (DASS-21), and BMI. Follow-up assessments will occur every 3 months. This study will provide objective evidence on the comparative efficacy of Folliculinum versus constitutional homeopathy in managing PCOS.