Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome - A Prospective Multicenter Study With Transcranial Doppler

Centro Hospitalar De São João, E.P.E.1 site in 1 country61 target enrollmentJune 6, 2019

ConditionsInfarction, Brain Embolism Atrial Fibrillation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Infarction, Brain
Sponsor: Centro Hospitalar De São João, E.P.E.
Enrollment: 61
Locations: 1
Primary Endpoint: Prevalence of MES
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF. All centers will use the same transcranial Doppler machine for one-hour monitoring with bilateral 2-MHz probes within 24 hours of symptom onset. Recordings will be analyzed for MES by a blinded central reader. The primary aim is to determine the proportion of patients with MES and the association of MES with functional outcomes assessed by a modified Rankin scale (mRS) score at 90 days.

Registry

clinicaltrials.gov

Start Date

June 6, 2019

End Date

October 6, 2022

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Centro Hospitalar De São João, E.P.E.

Responsible Party

Principal Investigator

Pedro Castro

Professor

Centro Hospitalar De São João, E.P.E.

Eligibility Criteria

Inclusion Criteria

•acute ischemic stroke admitted to the Stroke Unit, history of AF/flutter or a new diagnosis of AF at the stroke, and with a possibility to be monitored within 24 hours after symptom onset.