NCT06018090已完成不适用
Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome - A Prospective Multicenter Study With Transcranial Doppler
Centro Hospitalar De São João, E.P.E.1 个研究点 分布在 1 个国家目标入组 61 人开始时间: 2019年6月6日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- Prevalence of MES
研究概览
简要总结
This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF. All centers will use the same transcranial Doppler machine for one-hour monitoring with bilateral 2-MHz probes within 24 hours of symptom onset. Recordings will be analyzed for MES by a blinded central reader. The primary aim is to determine the proportion of patients with MES and the association of MES with functional outcomes assessed by a modified Rankin scale (mRS) score at 90 days.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute ischemic stroke admitted to the Stroke Unit, history of AF/flutter or a new diagnosis of AF at the stroke, and with a possibility to be monitored within 24 hours after symptom onset.
排除标准
- •use of anticoagulants at stroke onset; prosthetic valves; inadequate temporal bone window; uncooperative patients.
结局指标
主要结局
Prevalence of MES
时间窗: Within 24 hours of symptom onset
Poor functional outcome
时间窗: 90-days after stroke
次要结局
- Ordinal Shift Analysis of mRS scale score(90-days after stroke)
研究者
Pedro Castro
Professor
Centro Hospitalar De São João, E.P.E.
研究点 (1)
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