Differentiated thyroid carcinoma in children: Late effects of treatment and pathophysiological background in the Netherlands.
Completed
- Conditions
- Differentiated thyroid carcinoma, thyroid cancer, late effects, childIn Dutch:Gedifferentieerd schildkliercarcinoom, schildklierkanker, late effecten, kind
- Registration Number
- NL-OMON28040
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
Differentiated thyroid carcinoma diagnosed between 1970 and 2013 at age <19 years and treated in the Netherlands.
Exclusion Criteria
No exclusion criteria have been established for the study in its entirety. However, for evaluation of late effects including quality of life the following exclusion criteria are applicable:
1. DTC as a second malignancy;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint is the incidence of late effects of 131-I treatment and TSH suppressive therapy including quality of life.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are the presence of somatic mutations and relation with clinical outcome, miRNA (-146b, -181b, -21, -221, -222) expression profile, and incidence of family members with non-medullary thyroid carcinoma.