Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Incidence of cerebral vasospasm and delayed cerebral ischemia
研究概览
简要总结
The purpose of this study is to evaluate the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage patients.
详细描述
Adiponectin (APN) is an abundant protein hormone derived from adipose tissue. It has been suggested to exert anti-inflammatory, antiatherogenic, and vascular protective. Subarachnoid hemorrhage (SAH) comprises about 5% of all strokes with high mortality and permanent disability rates. Although many patients survive from the initial hemorrhage or rebleeding, they suffered from long-term delayed neurological deficits (DNDs), including stroke, delayed cerebral ischemia, cognitive and neuropsychological abnormalities that seriously impact overall function and quality of life. Ruptured cerebral aneurysms are the most common cause of SAH. There is growing evidence supporting APN act as a predictive factor for SAH. The observational study will focus on the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage (aSAH).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 90 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age>18yrs and age<90yrs
- •It shows subarachnoid hemorrhage (SAH) based on computed tomography (CT) scan on admission
- •Aneurysmal subarachnoid hemorrhage confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography (DSA)
- •SAH grade is assessed by Hunt & Hess classification
- •Informed consented
排除标准
- •Traumatic subarachnoid hemorrhage
- •Patients with cerebral herniation or highly possible to occur within 2 days from SAH
- •Length of hospital stay is expected to be less than 5 days
- •Duration from onset to admission is more than 48 hours
- •Disturbance of communication or poor compliance to blood collection, imaging examination and follow-up
结局指标
主要结局
Incidence of cerebral vasospasm and delayed cerebral ischemia
时间窗: 30 days post SAH
Proved by clinical and radiologic evidence
次要结局
- Death(30 days post SAH)
- National institutes of health stroke scale (NIHSS) score(On discharge or 14 days (whichever occurs first) and 30 days post SAH)
- Modified Rankin scale (mRS)(30 days and 90days post SAH)