Co-induction Ketamine-propofol: Effects on Laryngeal Mask Airway Insertion Conditions in Children
- Registration Number
- NCT03631875
- Lead Sponsor
- University Hospital, Mahdia
- Brief Summary
Background: Large doses of propofol needed for induction and laryngeal mask (LM) insertion in children may be associated with hemodynamic sides effects. Co-induction with low doses of ketamine 0.5 mg/ kg has the advantage of reducing dose and therefore maintaining hemodynamic stability.
Aim: To examine the effect of co-induction on LM insertion, hemodynamics and recovery in children
- Detailed Description
A prospective, randomized, double-blind, controlled study was conducted including120 ASA physical status I ⁄ II unpremedicated children, aged 1-8 years. Inhalatory induction with sevoflurane at 7% to insert an intravenous canula was first used then decreased to 2%. Normal saline or ketamine (0.5 mg/kg) were administered in groups P (propofol), PK (propofol-ketamine) respectively, 1 min prior to the administration of the induction dose of propofol. Propofol 3mg/kg was used for induction in the 2 groups, LM inserted 60 s later and insertion conditions assessed. Heart rate and blood pressure were recorded immediately after propofol bolus, then after LM insertion, at the 3rd ,5th and 10th minutes later. Recovery was assessed using Steward's Score
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
- American Society of Anesthesiologist (ASA) physical status I and II
- unpremedicated
- ambulatory surgery
- surgery complication
- upper air way complications
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description P (propofol), Ketamine normal saline is injected 01 min before induction with propofol 3 mg/kg. After 60 seconds, an experimented anesthesiologist evaluated the LM conditions insertion. PK (propofol-ketamine) Ketamine we inject 0.5 mg/kg of ketamine 01 min before induction with 03 mg/kg of propofol .Sixty seconds after, an experimented anesthesiologist evaluated the LM conditions insertion.
- Primary Outcome Measures
Name Time Method laryngeal masque conditions insertion MINUTE 1 When the jaw was relaxed, and deglutition and cough reflex and member movement were absent, the conditions were considered acceptable.the laryngeal masque was inserted
- Secondary Outcome Measures
Name Time Method hemodynamic conditions HOURS 1 systolic blood pressure
heart rate HOURS 1 cardiac frequence
Trial Locations
- Locations (1)
Mahdia University Hospital
🇹🇳Mahdia, Tunisia